PUBLICATIONS

 

 

PUBLICATIONS

LAB ABSTRACTS

 

 

  PUBLICATIONS
   

Lopez AI, Reins RY, McDermott AM, Trautner BW, Cai C. (2009) Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers. In press Molecular BioSystems.

Liu Q, McDermott AM, Miller WL. (2009) Elevated nerve growth factor in dry eye associated with established contact lens wear. In Press Eye and Contact Lens.

Tuckler Henriksson J, McDermott AM, Bergmanson JPG. (2009) Dimensions and morphology of the cornea in three strains of mice. Invest Ophthalmol Vis Sci. 50, 3648-3654.

McDermott AM. (2009) The Role of Antimicrobial Peptides at the Ocular Surface. Ophthalmic Res 41, 60-75.

Narayanan S, Corrales RM, Farley W, McDermott AM, Pflugfelder SP. (2008) Interleukin-1 Receptor-1 deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye. Cornea 27, 811-817.

Huang LC, Redfern RL, Narayanan S, Reins RY, McDermott AM. (2007) In vitro activity of human beta-defensin 2 against pseudomonas aeruginosa in the presence of tear fluid. Antimicrob Agents Chemother 51, 3853-3860.

Huang LC, Reins RY, Gallo RL, McDermott AM. (2007) Cathelicidin-deficient (Cnlp-/-) mice show increased susceptibility to Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 48, 4498-4508.

McDermott AM. (2007) Cationic antimicrobial peptides. A future therapeutic option? Arch Soc Esp Oftalmol 82, 467-470. (Editorial)

Huang LC, Jean D, Proske RJ, Reins RY, McDermott AM. (2007) Ocular surface expression and in vitro activity of antimicrobial peptides. Curr Eye Res. 32, 595-609.

Calabretta MK, Kumar A, McDermott AM, Cai C. (2007) Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups. Biomacromolecules 8, 1807-1811.

Pei Y, Reins RY, McDermott AM. (2006) Aldehydehydrogenase (ALDH)3A1 Expression by the Human Keratocyte and Its Repair Phenotypes. In Press Exp Eye Res.

Narayanan S, Manning J, Proske R, McDermott AM. (2006) The effect of hyperosmolality on b-defensin gene expression by human corneal epithelial cells. In Press Cornea

Narayanan S, Miller LW, McDermott AM. Conjunctival cytokine expression in symptomatic moderate dry eye subjects. Invest Ophthalmol Vis Sci. 2006, 47, 2445-2450.

Huang LC, Petkova TD, Reins RY, Proske RJ and McDermott AM. Multi-functional roles of human cathelicidin (LL-37) at the ocular surface. Invest Ophthalmol Vis Sci. 2006, 47, 2369-2380.

McDermott AM, Rich D, Cullor J, Mannis MJ, Smith W, Reid T, Murphy CJ. The in vitro activity of selected defensins against an isolate of Pseudomonas in the presence of human tears Br. J. Ophthalmol 2006, 90, 609-611.

McDermott AM, et al. (2005) Pathways of corneal and ocular surface inflammation. A perspective from the Cullen Symposium. The Ocular Surface 2005, 3s, s131-138.

Gordon YJ, Romanoswki EG, McDermott AM. A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr Eye Res 2005, 30, 505-515.

Gordon YJ, Huang LH, Romanowski EG, Yates KA, Proske RJ, McDermott AM. Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity. Curr Eye Res, 2005, 30, 385-394.

Narayanan S, Miller WL, Prager TC, Jackson JA, Leach NE, McDermott AM, Christensen MT, Bergmanson JPG. The diagnosis and characteristics of moderate dry eye in non-contact lens-wearers. Eye Contact Lens 2005, 31, 96-104.

Narayanan S, Glasser A, Hu Y-S and McDermott AM. The effect of Interleukin-1 on cytokine gene expression by human corneal epithelial cells. Exp Eye Res., 2005, 80, 175-183.

Huang LC, Jean D, McDermott AM. Effect of preservative free artificial tears on the antimicrobial activity of human b-defensin-2 and Cathelicidin LL-37 in vitro. Eye Contact Lens, 2004, 31, 34-38.

McDermott AM. Defensins and other antimicrobial peptides at the ocular surface. The Ocular Surface, 2004, 2, 229-247.

Pei Y, Sherry D and McDermott AM. Thy-1 distinguishes human corneal fibroblasts and myofibroblasts from keratocytes. Exp Eye Res. 2004, 79, 705-712.

Narayanan S, Miller WL and McDermott AM. Expression of human b-defensins in conjunctival epithelium : relevance to dry eye disease. Invest. Ophthalmol. Vis. Sci. 2003, 44, 3795-3801.

McDermott AM, Xiao TL, Kern TS and Murphy CJ. Non-enzymatic glycation in corneas from normal and diabetic donors and its effects on epithelial cell attachment in vitro.

Optometry 2003, 74, 443-452. McDermott AM, Redfern RL, Zhang B, Pei Y, Huang L and Proske RJ. Defensin expression by the cornea: multiple signaling pathways mediate IL-1b stimulation of hBD-2 expression by human corneal epithelial cells. Invest.

Ophthalmol. Vis. Sci. 2003, 44, 1859-1865. McDermott AM, Redfern RL and Zhang B. Human b-defensin 2 is up-regulated during re-epithelialization of the cornea. Curr. Eye Res. 2001, 22, 64-67.

JP Bergmanson and AM McDermott. Structural and functional consequences of photorefractive surgery. CE Optometry 2001, 4, 24-27.

  LAB ABSTRACTS
   

Manarang JC, Reins RY, McDermott AM (2009) Cytotoxicity of cationic antimicrobial peptides to ocular cells. Invest. Ophthalmol. Vis. Sci. e-abstract #923.

Liu Q, Gagen D, McDermott AM (2009) Nerve growth factor induces migration and differentiation of mouse monocytes. Invest. Ophthalmol. Vis. Sci. e-abstract #1950.

Redfern RL, Farley W, Pangelinan SB, De Pavia CS, Reins RY, McDermott AM, Pflugfelder SC (2009) Toll-like receptor expression is modulated in response to experimental dry eye. Invest. Ophthalmol. Vis. Sci. e-abstract #3652.

Hanlon S, Reins RY, McDermott AM (2009) Cytotoxic effects of latanoprost free acid on corneal stromal cells. Invest. Ophthalmol. Vis. Sci. e-abstract #4542.

Redfern RL, Reins RY, McDermott AM (2008) Toll-like receptor activation and antimicrobial peptide expression at the ocular surface. Optom Vis Sci E-abstract 85306.

Liu Q, McDermott AM, Miller WM (2008) Nerve growth factor is elevated in dry eye related to longterm contact lens wear. Optom Vis Sci E-abstract 85313.

Haselhorst E, Reins RY, McDermott AM (2008) Antimicrobial peptides and corneal wound healing. Invest. Ophthalmol. Vis. Sci. e-abstract #3392.

Qin G, McDermott AM, Cai C (2008) Influence of local concentration on the antimicrobial efficacy of the cathelicidin LL-37. Invest. Ophthalmol. Vis. Sci. e-abstract #4790.

Liu Q, Miller WL, Redfern RL, McDermott AM (2008) Effect of nerve growth factor (NGF) and hyperosmolar stress on corneal and conjunctival epithelial cell viability and expression of inflammation related molecules. Invest. Ophthalmol. Vis. Sci. e-abstract #432.

Chen LZ, Nichols R, McDermott AM, Pflugfelder S (2007) Osmolarity of preservation media determines the survival of human corneal epithelia. Optom Vis Sci 84, E-abstract 070028.

Tukler-Henriksson J, McDermott AM, Bergmanson JPG (2008) Structural explanation for central to peripheral thickness variation in the mouse cornea. Invest. Ophthalmol. Vis. Sci. e-abstract #3392.

Redfern RL, Baxter J, Reins RY, McDermott AM (2007) Toll-like receptor expression is modulated during dry eye conditions in vitro. Invest. Ophthalmol. Vis. Sci. e-abstract #3651.

Huang LC, Reins RY, Gallo RL, McDermott AM (2007) Cathelicidin-deficient (Cnlp-/-) mice show increased susceptibility to Pseudomonas keratitis. Invest. Ophthalmol. Vis. Sci. e-abstract #4725.

Petkova TD, Huang LC, Reins RY, McDermott AM (2007) Antimicrobial peptide expression in experimentally induced Pseudomonas aeruginosa keratitis in mice. Invest. Ophthalmol. Vis. Sci. e-abstract #2656.

Calabretta M, Kumar A, McDermott AM, Cai C (2007) Toxicity of Poly(amidoamine) dendrimers to common pathogenic bacteria and human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. e-abstract #2661.

Tukler-Hendriksson J, McDermott AM, Burns AR, Petrescu M, Bergmanson JPG (2007) Dimensional assessment of the cornea in two strains of mice. Invest. Ophthalmol. Vis. Sci. e-abstract #3503.

Petkova TD, Huang LC, Reins RY, McDermott AM. Effect of LL-37 (cathelicidin) on human corneal epithelial cell migration and cytokine secretion. Invest. Ophthalmol. Vis. Sci. 2006, e-abstract 5019.

Redfern RL, Rein RY, McDermott AM. Toll-like receptors and antimicrobial peptide expression at the ocular surface. Invest. Ophthalmol. Vis. Sci. 2006, e-abstract 4372.

McDermott AM, Pei Y. Novel role for Thy-1 in mediating corneal fibroblast attachment to extracellular matrix proteins. Invest. Ophthalmol. Vis. Sci. 2006, e-abstract 5042.

McDermott AM, Pei Y, Sherry DM. Corneal Crystallin Expression in Human Repair Phenotype Keratocytes. Ophthal Res. 2005, 37, S1, #4466, 217.

Huang LC, Jean D, Proske RJ, McDermott AM. Innate immunity at the ocular surface: Spectrum of antimicrobial peptide expression. Invest. Ophthalmol. Vis. Sci. 2005, e-abstract 883.

Hughes BJ, Segu P, Narayanan S, Morris C, Venugopal M, Chapoy L, McDermott AM, Bergmanson JP, Carney FP. Contact Lenses as a diagnostic tool I: The uptake and release of steroid hormones by commercial hydrogel lenses. Invest. Ophthalmol. Vis. Sci. 2005, e-abstract 2072.

Segu P, Hughes BJ, Narayanan S, Carney FP, Morris C, Venugopal M, Chapoy L, Y Lvov, McDermott AM, Bergmanson JP. Contact Lenses as a diagnostic tool II: Hormone uptake by poly-electrolyte coated surfaces and contact lenses. Invest. Ophthalmol. Vis. Sci. 2005, e-abstract 2073.

Narayanan S, Corrales RM, Farley W, McDermott AM, Pflugfelder SC. IL-1R1-deficient mice show altered ocular surface cytokine and defensin expression in experimental dry eye. Invest. Ophthalmol. Vis. Sci. 2005, e-abstract 4467.

McDermott AM, Huang LC, Narayanan S. Effect of Human Tears on Cationic Antimicrobial Peptide Activity in Vitro. Ophthal. Res. 2004, 36, S1, #2311, 153

Gordon Y, Romanowski EG, Yates KA and McDermott AM. Human cathelicidin (LL-37-hCAP18) demonstrates direct antiviral activity against adenovirus and herpes simplex virus in vitro. Invest. Ophthalmol. Vis. Sci. 2004, e-abstract 2256.

Huang LC, Proske RJ and McDermott AM. Functional roles of the epithelial derived antimicrobial peptide LL-37 at the ocular surface. Invest. Ophthalmol. Vis. Sci. 2004, e-abstract 4940.

Pei Y and McDermott AM. Thy-1 expression and function in keratocyte repair phenotypes. Invest. Ophthalmol. Vis. Sci. 2004, e-abstract 4871.

Narayanan S, Miller WL and McDermott AM. Conjunctival cytokine expression in symptomatic moderate dry eye subjects. Invest. Ophthalmol. Vis. Sci. 2004, e-abstract 86.

Redfern RL, Proske RJ and McDermott AM. Effect of defensins on corneal cell migration and cytokine production. Invest. Ophthalmol. Vis. Sci. 2004, e-abstract 4866.

Jean D, Huang LH, McDermott AM. Effect of ophthalmic solutions on the antimicrobial activity of human b-defensin-2 and LL-37. Optom & Vision Sci 2003, 80, p105.

Huang LH, Proske RJ, McDermott AM. Expression of the peptide antibiotic LL-37-hCAP 18 (cathelicidin) by human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 2003, e-abstract 1335.

Pei Y, Sherry DM, McDermott AM. Thy-1, a marker for corneal fibroblasts. Invest. Ophthalmol. Vis. Sci. 2003, e-abstract 869. Narayanan S and McDermott AM. Proinflammatory cytokines upregulate human b-defensin-2 expression in conjunctival epithelial cells:relevance to dry eye disease. Invest. Ophthalmol. Vis. Sci. 2003, E-abstract 2490.

McDermott AM, Redfern RL, Narayanan S and Proske RJ. Effect of defensins on human corneal epithelial cell migration. Invest. Ophthalmol. Vis. Sci. 2003, e-abstract 4754.

Narayanan S, Manning J, Proske R, and McDermott AM. The effect of hyperosmolality on beta defensin gene expression by human corneal epithelial cells. Optom & Vision Sci. 2002, 79, p245.

Redfern RL, Pei Y and McDermott AM. Cytokine stimulated up-regulation of human b-defensin-2 expression in corneal epithelial cells is mediated via activation of NFkB. Invest. Ophthalmol. Vis. Sci. 2002, 42, #1639.

McDermott AM, Proske RJ, Woo HM, Campbell S and Murphy CJ. Rat b-defensin-2 is upregulated during corneal re-epithelialisation in vivo. Invest. Ophthalmol. Vis. Sci. 2002, 42, #4198.

Narayanan S and McDermott AM. The effect of interleukin-1 on cytokine gene expression by human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 2002, 42, #3201.

Huang L, Narayanan S, Redfern RL, McDermott AM. Human tears inhibit the anti-microbial activity of human-b-defensin-2 in vitro. Invest. Ophthalmol. Vis. Sci. 2002, 42, #82.

McDermott AM, Redfern RL, Narayanan S, Zhang B and Proske RJ. Antimicrobial b-defensin peptides are up-regulated in ocular surface cells in response to cytokines and bacterial exposure. Clin Exp. Ophthalmol. 2002, 30, P302, A227.

Zhang B and McDermott AM. Cytotoxicity of defensins to SV40 human corneal epithelial cells and primary-cultured human corneal fibroblasts. Invest. Ophthalmol. Vis. Sci. 2001, 42, #212, s37.

McDermott AM, Huang L, Zhang B and Redfern RL. The antimicrobial peptide human b -defensin-2 is upregulated during corneal-re-epithelialisation. Invest. Ophthalmol. Vis. Sci. 2001, 42, #4762, s887.

Narayanan S, Redfern RL, Bergmanson JPG and McDermott AM. Human beta defensin 2 is upregulated in the conjunctival epithelium of subjects with moderately dry eyes. Invest. Ophthalmol. Vis. Sci. 2001, 42, #2624, s486

Tran NK, Huang L, Redfern RL and McDermott AM. Antimicrobial b-defensins are expressed by bovine ocular surface cells and are upregulated during corneal epithelial regeneration. Invest. Ophthalmol. Vis. Sci. 2001, 42, #4763, s887.

Redfern RL, Zhang B and McDermott AM. Pro-inflammatory cytokines upregulate the expression of the antimicrobial peptide, human b-defensin-2 in human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 2001, 42, #199, s35.

McDermott AM, Redfern R and Tran N. Increased expression of antimicrobial peptides in the corneal epithelium during wound healing. Optom & Vision Sci. 2000, 77, VB104, 154.

McDermott AM and Xiao TL. Non-enzymatic glycation in normal and diabetic human cornea and its effects on epithelial cell attachment. Invest. Ophthalmol. Vis. Sci. 2000, 41 (4), # 1361, s259.